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Old July 24th, 2011, 09:09 PM
Tony Lance Tony Lance is offline
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Default Prof. Marco Ruggiero on his work with GcMAF & probiotic yogurt

Given my longstanding interest in intestinal health and gut flora and their connection to “HIV/AIDS”, I was understandably excited when I received the news of Prof. Marco Ruggiero’s recent work involving GcMAF and a specially formulated probiotic yogurt. And as you might imagine I had lots of questions. Ruggiero and I exchanged a series of emails and what follows is the background on this line of research, in Ruggiero's own words and published with his permission.

We at QA expect readers to have additional questions. Although this is a moderated thread please post them and we will pass them on to Prof. Ruggiero. If we have a few glitches at first—this is something new we're trying, after all—be patient with us.—Tony Lance


We have been working on vitamin D and its receptor (vitamin D receptor, VDR) for many years, identifying the VDR gene profiles associated with a number of physiological and pathological conditions. Vitamin D, VDR and vitamin D binding protein are called “vitamin D axis”. (You can find our papers here.) Therefore, when Prof. Yamamoto in 2009 published his paper claiming that GcMAF [Gc protein-derived macrophage activating factor] eradicated HIV without antiretroviral therapy (ART), it was only natural for us to direct our attention to GcMAF because it belongs to the vitamin D axis in that GcMAF derives from vitamin D binding protein, also known as Gc-protein.

In addition to the basic science interest, we were also attracted by the possibility to demonstrate in the laboratory that the famous words of Prof. Montagnier—“…you will get rid of the virus in a few week if you have a good immune system”—were true. Not that we doubted his words, but we knew that his words were based upon his clinical observations and not on actual experiments performed in the laboratory. The rationale is simple: if GcMAF administration eradicates HIV infection as published by Prof. Yamamoto, since GcMAF is not an antiretroviral and it should do no harm to the virus, this demonstrates that an empowered immune system is able to eliminate HIV and prevent AIDS. This would in turn demonstrate that immunodeficiency is the cause of chronic HIV infection and not vice-versa. In addition, this approach, often referred to as “immunotherapy”, would shift the focus from the fight against the virus to the effort to re-establish, or empower, an immune system made deficient by a number of different causes, probably different for each individual.

I often use the following example from my previous experience in lung cancer research. Even though many lung cancer patients are heavy smokers, lung cancer occurs also in non-smokers. Imagine you are an oncologist dealing with lung cancer patients. It makes no sense and it is criminal to abstain from using available anti-cancer therapeutic strategies (surgery, radio- or chemotherapy) and instead have all the lung cancer patients attend courses or counseling to stop smoking. This is what happens with AIDS; instead of focusing on the real disease, immunodeficiency, they try to fight the virus that putatively causes it, paying the high price of severe side effects, among which is drug-induced immunodeficiency, while at the same time ignoring the immune system without trying to reinforce it.

Because of these considerations, we thought that immunotherapy with GcMAF would be a good object of study. There was also another consideration. AIDS diagnosis and the decision to initiate ART are based on CD4 cell count. Therefore, we reasoned, if we are able to keep them high, HIV+ people, in addition to staying healthy, will avoid prescription of ART and will not be classified as having AIDS.

We had just recently read a very interesting article by Reid et al. (quoted in our IAS2011 presentation) where he demonstrated that a probiotic yogurt was able to rise CD4 to an extent comparable to that of ART, obviously without side effects and practically at no cost. In fact, it was produced by local women in low-income communities in Tanzania. In other words, locally-produced probiotic yogurt produced the same effects of ART. Or, if you prefer, AIDS in Africa can be defeated at no cost and with no side effects.

Reid et al. did not provide a molecular mechanism underlying the observed effects on CD4 cell count. We thought that bacteria contained in their probiotic yogurt could have converted some Gc-protein that is present in low concentration in milk into active GcMAF. Thus, administration of Reid’s probiotic yogurt might have mimicked Yamamoto’s administration of GcMAF.

Based on these premises, we then studied a way to have certain strains of bacteria convert high concentration of Gc-protein into GcMAF and we developed MAF 3 14. This was not easy at all and the number 314 indicates the number of different combinations/experiments we had to perform before obtaining the right conditions. This is definitely not something that you could perform in your home kitchen! Then, we thought that it could have been cooler to call it 3 14 mimicking the p number.

We also took advantage of the deep knowledge of human anatomy and histology of Prof. Stefania Pacini who is professor of human anatomy at the Faculty of Medicine of the University of Firenze. In fact, she let us know that there was no need to inject MAF 3 14 (an impossible task) if we wished to stimulate the immune system. The existence of the mucosa-associated lymphoid tissue (MALT) that comprises macrophages is now widely recognized and activated macrophages can re-circulate between mucosas, blood, tissues, and back to mucosas. At this point the only remaining obstacle was the acid environment of the stomach that could have digested the GcMAF presented in MAF 3 14. This problem also was solved by Prof. Pacini’s knowledge of human anatomy. In fact, in the Waldeyer’s tonsilar ring there is an abundance of macrophages that can be directly stimulated by the GcMAF present in MAF 3 14. Not only that, we developed a way to have most MAF 3 14 pass intact the gastric environment and arrive intact (for the most part) in the lower intestine where the gut microbiota (now conceived as a virtual organ) exerts its actions.

In fact, MAF 3 14 is not only a GcMAF-enriched yogurt. Based on Reid’s publications and successes, MAF 3 14 was developed to re-establish a healthy gut microbiota, very similar to that of newborn mammals. A sort of reset of the gut microbiota. Again, this achievement was not easy. Please consider that we had to do more than two experiments a day in a fully equipped and well funded laboratory. We often worked 14 hours a day with a team of about 10 researchers; you can see some of them in the home page of www.marcoruggiero.org. Prof. Pacini is the third from the left, standing.

At that point, we began experimenting on ourselves as true scientists of the old days used to do. (I wonder how many advocates of ART have experienced those drugs on themselves.) You can see the results of this “trial” in IAS2011. Immediately thereafter, we gave MAF 3 14 to a couple of friends with different pathologic conditions and we are now monitoring their situation. By the way, MAF 3 14 has a good taste and people who tried it found it good. We are collecting a series of unexpected positive side-effects that we believe are due to the lucky combination of immune stimulation and re-establishment of a healthy gut microbiota. Many of these effects are just sensations difficult to quantify in scientific terms, but they are nevertheless very welcomed by those experiencing them.

I conclude, for the moment, letting you know that we are about to move to the U.S. to perform a larger scale trial. I cannot give at the moment more details about this. If everything works as we hope and believe, MAF 3 14 should be available for consumption in the coming weeks.—Prof. Marco Ruggiero

Last edited by Tony Lance; July 25th, 2011 at 01:47 AM.
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Old July 24th, 2011, 11:44 PM
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Default Re: Prof. Marco Ruggiero on his work with GcMAF & probiotic yogurt

Prof. Ruggerio,

First, let me thank you for the fascinating work that you have been presenting of late. I certainly do appreciate it, particularly given that I'm one of the adventurous souls using GcMAF in a sort of ad hoc trial.

The idea that it might be possible to reset the intestinal microbiota seems to be potentially quite powerful, not only for those that are HIV positive but even in simpler cases where a normal patient has taken a course of antibiotics for a bacterial infection, which is now known to cause side-effects for many years.

As such, it would seem that MAF 3 14 would also have substantial potential commercial value. Have you filed for or is it your intent to file for patent protection on MAF 3 14? I ask because for those of us not located in Italy or the US, it might prove quite difficult to obtain (perhaps not so much for me personally, since I'm only 40km from the US border, but still of interest to those not so fortunate.)
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Old July 26th, 2011, 10:38 AM
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Default Re: Prof. Marco Ruggiero on his work with GcMAF & probiotic yogurt

This is very exciting news. I have utilized the services of a well-respected orthomolecular research facility that operates free of the influence of the NIH and pharma grant system. The doctor there is aware of GcMAF, and has expressed an interest in doing research with it. While they are primarily involved with cancer patients, they are open to working with patients with other conditions, including "HIV/AIDS".

I would be glad to introduce you to the center's research and development director, if you are interested. I would also be willing to be a trial participant. I love yogurt!

Quote:
Originally Posted by Tony Lance View Post


I conclude, for the moment, letting you know that we are about to move to the U.S. to perform a larger scale trial. I cannot give at the moment more details about this. If everything works as we hope and believe, MAF 3 14 should be available for consumption in the coming weeks.—Prof. Marco Ruggiero
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Old July 27th, 2011, 02:09 PM
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Default Re: Prof. Marco Ruggiero on his work with GcMAF & probiotic yogurt

Quote:
Originally Posted by computergeek View Post
Prof. Ruggerio,

First, let me thank you for the fascinating work that you have been presenting of late. I certainly do appreciate it, particularly given that I'm one of the adventurous souls using GcMAF in a sort of ad hoc trial.
Thank you for your words. Just yesterday we had the blood tests performed after 8 weeks treatment. Results were even more encouraging. Increase in Natural Killer lymphocytes accompanied normalization of CD4 and CD8. I am in the process of representing those data as graphs.

Quote:
The idea that it might be possible to reset the intestinal microbiota seems to be potentially quite powerful, not only for those that are HIV positive but even in simpler cases where a normal patient has taken a course of antibiotics for a bacterial infection, which is now known to cause side-effects for many years.
We fully agree with this consideration. As a matter of fact, GcMAF was proven effective in a variety of pathological conditions, from cancer to Lupus to chronic fatigue syndrome. The lucky combination of a GcMAF-enriched product coupled with its ability to restore a healthy gut microbiota might indeed prove useful almost in everybody. In our little preliminary trial on ourselves, we noticed that also subjects with normal values had an improvement of those values consistent with a stimulation of the immune system, a condition that is always welcomed.

Quote:
As such, it would seem that MAF 3 14 would also have substantial potential commercial value. Have you filed for or is it your intent to file for patent protection on MAF 3 14? I ask because for those of us not located in Italy or the US, it might prove quite difficult to obtain (perhaps not so much for me personally, since I'm only 40km from the US border, but still of interest to those not so fortunate.)
We are about to fly to the US also to try to solve these practical problems. If things actuate as we hope, you should be able to get MAF 3 14 at home.

Last edited by Tony Lance; July 27th, 2011 at 02:17 PM.
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Old July 29th, 2011, 05:30 AM
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Default Re: Prof. Marco Ruggiero on his work with GcMAF & probiotic yogurt

Dear prof. Ruggiero,
Do you consider it a must to take the VDR genotype test before ordering GCMAF or will there be a benefit anyway? I just got tested for vitamin D OHD3 and it came out to 56ng/ml which is considered normal. I have been taking 5000IU vitamin D3 daily for at least 6 months.
I just ordered the best probiotic that I could find with 18 strands in stomach acid resistant capsules http://www.iherb.com/Healthy-Origins...aps/19518?at=0
I also ordered some kefir starter.
Thanks for your work, you have given us a great gift!
Truth Seeker
Hong Kong

Last edited by Tony Lance; July 29th, 2011 at 12:50 PM. Reason: minor spelling error
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Old July 29th, 2011, 08:32 PM
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Default Re: Prof. Marco Ruggiero on his work with GcMAF & probiotic yogurt

Dear Truth Seeker,

A VDR test will be useful to determine the degree of responsiveness to GcMAF. Please do not self-administer yourself any drug or compound without medical supervision, in particular if those compounds are to be injected. If you take vitamin D, please consider that it accumulates in the body and vitamin D intoxication can occur. Please remember to drink at least two liters of good spring water in order to prevent kidney stones. Kefir and probiotics are always a good addition to a healthy diet. However, they have little or nothing to do with MAF 3 14.
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Old July 30th, 2011, 01:47 AM
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Dear Prof. Ruggiero,

Is it possible to be a totally non-responder to GcMAF or will it take just more time to respond?
If the VDR test result come as non-responder, is there a solution to boost responsiveness? Will MAF314 replace GcMAF, having the same effect on the immune system?

Thanks.

Last edited by Tony Lance; July 30th, 2011 at 12:46 PM.
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Old July 30th, 2011, 01:24 PM
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Default Re: Prof. Marco Ruggiero on his work with GcMAF & probiotic yogurt

Truth Seeker,

In vitro, monocytes from patients with certain VDR genotypes do not respond to chemical GcMAF; please see our poster at the Vienna conference on AIDS in 2010. The few data that we have in patients seem to indicate that some patients do not respond also. We have no data on prolonged treatment with chemical GcMAF. MAF 3 14 is a totally different thing in that it contains an array of probiotics in addition to GcMAF. We are about to perform trials to see whether VDR genotype is associated also with responsiveness to MAF 3 14. I believe that MAF 3 14 has not to be considered a substitute for GcMAF but rather an all natural way to provide non-chemical GcMAF to the organism in addition to a beneficial array of probiotics. At variance with chemical GcMAF, it is quite likely that MAF 3 14 will exert its effects even when the patient assumes other types of drugs. We are performing observation in this regard right now.
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Old July 31st, 2011, 01:19 AM
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Default Re: Prof. Marco Ruggiero on his work with GcMAF & probiotic yogurt

Can I participate in the trial? I live in Hong Kong.
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Old July 31st, 2011, 11:27 AM
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Default Re: Prof. Marco Ruggiero on his work with GcMAF & probiotic yogurt

Dear Prof Ruggiero,

What can I say? The world is a better place because you and your collegues are in it! Thank you for the invaluable work you are doing.

I realise that this is early days for MAF 3 14 and so many things will be unquantifiable so maybe there is no answer to this question just yet but I'd like to ask it anyway: at this stage, do you think it would be allowed/advisable/acceptable to use MAF 3 14 after having completed many months on the chemical GcMAF?

I am a VDR high responder and while I have had good effects from it, I have some nasty side effects too and lose all the benefits as soon as I stop taking it.

Any thoughts - either way - would be deeply appreciated. Good luck with your trip to USA, I hope it will be very productive.

Kind regards,

See Hope.

Last edited by Tony Lance; July 31st, 2011 at 12:58 PM. Reason: Misspellings
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