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Thread: Q&A: The Perth Group

  1. #31
    Join Date
    Nov 2011
    Posts
    16

    Default Re: Q&A: The Perth Group

    QUESTION

    Lastly, I will close by citing a few studies on the possible immunosuppressive effects of strenuous exercise, in order to demonstrate that a strong claim can be made just for this one factor alone:

    "A trauma-like elevation of plasma cytokines in humans in response to treadmill running."

    Abstract: 1. Elevated levels of cytokines, especially interleukin (IL)-6 and IL-1ra, can be measured in the plasma of athletes after exhaustive long term exercise.
    2. The present study investigates the kinetics of several cytokines and chemokines in ten male athletes before, during and after 2.5 h of treadmill running at 75% of maximal oxygen consumption (VO2,max). Blood was sampled before, every half-hour during running and every hour in the following 6 h recovery period.
    3. The plasma concentration of IL-6 increased after 30 min of running, and peaked at the end of running with a 25-fold increase compared with the pre-exercise value. IL-1ra increased only after running, and peaked after 2 h of rest with an 18-fold increase compared with the pre-exercise value. No changes were found in the concentrations of IL-1β, tumour necrosis factor (TNF)α, IL-15 and macrophage inflammatory protein (MIP)-1β, and the concentrations of IL-8 and MIP-1α were below detection limits.
    4. The results suggest that very early events in exercise trigger the release of IL-6, and that the cytokine response to exercise has similarities to that observed after trauma.

    http://jp.physoc.org/content/513/3/889.full

  2. #32

    Default Re: Q&A: The Perth Group

    We agree with you. Repeated strenuous exercise leads to cellular oxidation.
    Visit The Perth Group online.

  3. #33
    Join Date
    Feb 2009
    Posts
    1,811

    Default Re: Q&A: The Perth Group

    This concludes our Q&A with The Perth Group.

    They have my heartfelt gratitude for the obvious investment of time this has represented for them. Their answers have been very enlightening for me and no doubt for many others here.

    We will collate some of the questions engendered by TPG's replies and forward them to Eleni and Val. As answers always raise more questions, we are doing this for their reference and with no expectations of further replies.

    Eleni and Val, thank you and allow me to say that we hold your work in high regard and we speak very highly of it. Its scholarship stands like a lighthouse in a storm.

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