View Full Version : Scientists make HIV strain that can infect monkeys

March 3rd, 2009, 08:33 PM
This article (http://uk.reuters.com/article/scienceNewsMolt/idUKTRE52203620090303?sp=true) just posted on Reuters sure raises a lot of questions.
Scientists have created a strain of the human AIDS virus able to infect and multiply in monkeys in a step toward testing future vaccines in monkeys before trying them in people, according to a new study.
This strain of HIV, the human immunodeficiency virus, was developed by altering a single gene in the human version to allow it to infect a type of monkey called a pig-tailed macaque, the researchers said on Monday.
The genetically engineered virus, once injected into this monkey, proliferates almost as much as it does in people, but the animal ultimately suppresses it and the virus does not make it sick, they said.
The strain is called simian-tropic HIV-1, or stHIV-1...
How are They able to alter a gene on a virus that hasn't been isolated?

And what's the big deal if it doesn't cause AIDS?
But after initially spreading in the monkey's body, the animal succeeds in suppressing the virus -- not completely clearing the virus but driving it to very low levels.
"The slight problem is the monkeys don't go on to develop AIDS, they don't get sick," Bieniasz said.
What are they measuring here? Actual virus, or "antibodies"?

Another MSM article that reeks. Now there's a "monkey" "human immunodeficiency virus". That doesn't even sound like it could make sense.

March 3rd, 2009, 09:45 PM
I'll guess that they ordered up some "infectious HIV clones." Anyone know for sure? Here's an example:

QUOTE: An infectious clone containing P222A mutation in Gag was generated using a plasmid kindly provided by Drs. D. Braaten and J. Luban (5). UNQUOTE.

Source: http://www.jbc.org/cgi/content/full/281/2/1241